产品货号：
Z17975
中文名称：
HICE1/HAUS8抗体
英文名称：
Anti-HICE1/HAUS8 Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HICE1/HAUS8 Antibody |
| 指标别名 | HAUS8;HAUS augmin-like complex subunit 8;HEC1/NDC80-interacting centrosome-associated protein 1;Sarcoma antigen NY-SAR-48;HICE1 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB |
| 基因名称 | HAUS8 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-HICE1 was prepared from whole rabbit serum produced by repeated immunizations with a recombinant full length Hice1 protein. |
| 计算分子量 | 45kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This product was adsorbed against GST from monospecific antiserum by immunoaffinity chromatography.This antibody reacts with endogenous Hice1 protein.A BLAST analysis was used to suggest reactivity with Hice1 from human based on a 100% homology with the immunizing sequence.Expect reactivity with Hice1 from chimpanzee,Sumatran orangutan based on a 90% homology with the immunizing sequence.Cross-reactivity with Hice1 from other sources has not been determined. |
| 浓度 | 38mg/mL by Refractometry |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | This antibody is suitable for Cancer,Immunology and Nuclear Signaling research.Hice1 contributes to the mitotic spindle assembly,maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.Normal bipolar spindle formation is critical for accurate chromosome segregation and proper mitotic progression.Failure in this event leads to spindle checkpoint activation and chromosome missegregation that ultimately leads to aneuploidy.Hice1 binds to microtubules directly,and promotes spindle integrity and chromosome stability.Hice1 has also shown to play an important role in targeting the gamma TuRC complex to the mitotic spindle,a step that appears to be required for spindle-mediated microtubule generation and normal chromosome segregation.The HAUS augmin-like complex's interaction with microtubules is strong during mitosis,while it is weak or absent during interphase.During interphase,it is primarily cytoplasmic,associating with centrosomes and with the mitotic spindles,preferentially at the spindle pole vicinity.During anaphase and telophase,it additionally associates with the spindle midzone and midbody,respectively.Further characterization of the function of Hice1 will likely be important for better understanding the mechanism of normal mitotic progression and high fidelity chromosome segregation. |
| Uniprot ID | Q9BT25 |
| 基因名全称 | HAUS augmin-like complex subunit 8 |
| 推荐稀释比 | ELISA:1:250,000 WB:1:10,000 |
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